Los Alamos National Laboratory Computational Systems Biology Postdoctoral Researcher in Los Alamos, New Mexico

What You Will Do_
The successful candidate will develop, analyze, and guide experimental tests of computational models for cancer-relevant cellular regulatoy systems. These models will incorporate empirically determined parameter values, reproduce key experimental observations, and account for and integrate long-standing and newly obtained mechanistic knowledge. One goal is to advance system-level understanding of the cellular regulatory networks surrounding RAS, particularly the KRAS4B isoform. The new models will consider feedback and feedforward loops, oligomerization, clustering and trafficking of signaling proteins, and include a comprehensive treatment of RAS interactions with effectors, in particular heterodimers of the serine/threonine protein kinases BRAF and CRAF. Most importantly, the models will be designed to capture effects of distinct disease-associated mutations (e.g., the effects of the oncogenic RAS mutations G12V, G12D, Q61L, and G13D) and molecularly targeted drugs (e.g., RAF kinase inhibitors). An improved system-level understanding of RAS regulation has the potential to aid in the design of molecularly targeted therapies for cancers involving KRAS driver mutations, which encompass approximately 1/3 of all cancer cases and nearly all cases of pancreas cancer.

What You Need

Minimum Job Requirements:

The ideal candidate would have experience in the following areas:

  • Cell signaling and RAS biology

  • Biological rule-based modeling, especially experience using BioNetGen

  • Parameter estimation

  • Uncertainty quantification

  • Scientific programming

  • Coordination of modeling and experimental efforts

Education: PhD in related field within the past five years or soon to be completed. Must be complete by commencement of appointment.

Notes to Applicants: Please attach your CV and a cover letter that highlights your unique skills and experiences and explains your interests in the opening.

Additional Details:

No Clearance: Position does not require a security clearance. Selected candidates will be subject to drug testing and other pre-employment background checks.

New-Employment Drug Test: The Laboratory requires successful applicants to complete a new-employment drug test and maintains a substance abuse policy that includes random drug testing.

Candidates may be considered for a Director's Postdoc Fellowship and outstanding candidates may be considered for the prestigious Richard P. Feynman, Darleane Christian Hoffman, J. Robert Oppenheimer, or Frederick Reines Distinguished Postdoc Fellowships.

For general information go to Postdoc Program.

Equal Opportunity:

Los Alamos National Laboratory is an equal opportunity employer and supports a diverse and inclusive workforce. All employment practices are based on qualification and merit, without regards to race, color, national origin, ancestry, religion, age, sex, gender identity, sexual orientation or preference, marital status or spousal affiliation, physical or mental disability, medical conditions, pregnancy, status as a protected veteran, genetic information, or citizenship within the limits imposed by federal laws and regulations. The Laboratory is also committed to making our workplace accessible to individuals with disabilities and will provide reasonable accommodations, upon request, for individuals to participate in the application and hiring process. To request such an accommodation, please send an email to applyhelp@lanl.gov or call 1-505-665-4444 option 1.

Where You Will Work

Located in northern New Mexico, Los Alamos National Laboratory (LANL) is a multidisciplinary research institution engaged in strategic science on behalf of national security. LANL enhances national security by ensuring the safety and reliability of the U.S. nuclear stockpile, developing technologies to reduce threats from weapons of mass destruction, and solving problems related to energy, environment, infrastructure, health, and global security concerns.

The Theoretical Biology and Biophysics Group is one of six groups in the Laboratory’s renowned Theoretical Division. It was founded in 1974 and played a key role in establishing GenBank, the international HIV databases, and the rationale for combination therapy of HIV/AIDS. The scientific staff includes members of the US National Academy of Sciences and the American Academy of Arts & Sciences, as well as a winner of the E.O. Lawrence Award. Research in the group is focused on bioinformatics, simulation studies of biomolecules, and systems-level modeling, which is typically performed in collaboration with quantitative experimentalists. The US Department of Energy (DOE) and Los Alamos National Laboratory recognize that understanding complex biological systems is essential for public health and national security and strongly supports and encourages research in this area. For example, as part of DOE’s Exascale Computing Project (ECP), the Laboratory is pursuing advanced modeling and simulation solutions in support of the National Cancer Institute’s Precision Medicine Initiative. This work, launched in fall 2016, is being performed as part of an “application development” project entitled “Exascale Deep Learning and Simulation Enabled Precision Medicine for Cancer.”

Location: Los Alamos, NM, US

Contact Name: Hlavacek, William Scott

Organization Name: T-6/Theoretical Biology and Biophysics

Email: wish@lanl.gov

Job Title: Computational Systems Biology Postdoctoral Researcher

Appointment Type: Postdoc

Req ID: IRC69822